DOR YESHORIM, BY THE NUMBERS
In the past three months: January – March 2026
- 10,127 individuals were screened for pre-marital genetic testing.
- 15,404 potential couples (30,808 individuals) called the hotline to request a
compatibility check. - 220 compatibility requests resulted in ‘incompatible’, and genetic counseling was
offered to those individuals and their families (see chart below). - 620 specialized tests were administered for families with rare genetic diseases.
- 94 new families suffering from yet-to-be-identified genetic diseases reached out to Dor
Yeshorim for assistance. Dor Yeshorim is working to meet their needs.
The 220 incompatible results saved families from the following genetic diseases:
| Standard Panel | |
| Aicardi-Goutières Syndrome Type 5 (SAMHD1-Related) | 1 |
| Congenital Amegakaryocytic Thrombocytopenia (CAMT) | 3 |
| Bloom Syndrome (BLM-Related) | 1 |
| Canavan Disease (ASPA-Related) | 7 |
| Cerebellar Ataxia with Developmental Delay (THG1L-Related) | 1 |
| Congenital Heart Defects and Other Structural Anomalies (GDF1-Related) | 7 |
| Cystic Fibrosis (CFTR-Related) | 30 |
| Dermatosparaxis Ehlers-Danlos Syndrome (ADAMTS2-Related) | 3 |
| Dihydrolipoamide Dehydrogenase Deficiency (Lipoamide Dehydrogenase Deficiency) | 5 |
| Familial Dysautonomia (Riley-Day Syndrome, ELP1-Related) | 28 |
| Fanconi Anemia Complementation Group C (FANCC) | 1 |
| Classic Galactosemia (GALT-Related) | 2 |
| Glycogen Storage Disease Type Ia (von Gierke Disease) | 2 |
| Glycogen Storage Disease Type III (Debranching Enzyme Deficiency) | 1 |
| Familial Hyperinsulinism (Congenital Hyperinsulinism, ABCC8-Related) | 5 |
| Hypomyelinating Leukodystrophy (VPS11-Related) | 2 |
| Joubert Syndrome Type 2 (TMEM216-Related) | 1 |
| Methylmalonic Aciduria and Homocystinuria, cblC Type (MMACHC-Related) | 1 |
| Mitochondrial Complex V Deficiency, Nuclear Type 6 (USMG5-Related) | 2 |
| Mucolipidosis Type IV (MCOLN1-Related) | 2 |
| Nemaline Myopathy Type 2 (NEB-Related) | 1 |
| Niemann-Pick Disease Type A/B (SMPD1-Related) | 1 |
| Autosomal Recessive Polycystic Kidney Disease (ARPKD, PKHD1-Related) | 3 |
| Retinitis Pigmentosa 28 (FAM161A-Related) | 2 |
| Retinitis Pigmentosa 59 (DHDDS-Related) | 2 |
| Smith-Lemli-Opitz Syndrome (DHCR7-Related) | 7 |
| Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SLC1A4-Related) | 1 |
| Spinal Muscular Atrophy | 2 |
| Surfactant Metabolism Dysfunction, Pulmonary Type 3 (ABCA3-Related) | 2 |
| Tay-Sachs Disease (HEXA-Related) | 14 |
| Tyrosinemia Type 1 (Fumarylacetoacetase Deficiency) | 1 |
| Usher Syndrome Type 1F (PCDH15-Related) | 1 |
| Ventriculomegaly with Cystic Kidney Disease (CRB2-Related) | 2 |
| Walker-Warburg Syndrome (FKTN-Related) | 8 |
| Warsaw Breakage Syndrome (DDX11-Related) | 2 |
| Wilson Disease (ATP7B-Related) | 7 |
| Wolfram Syndrome 1 | 4 |
| 3MC Syndrome (COLEC10-Related) | 2 |
| Hearing Loss Panel | |
| Autosomal Recessive Nonsyndromic Hearing Loss (DFNB1/GJB2) | 29 |
| Autosomal Recessive Nonsyndromic Hearing Loss (DFNB18B/OTOG) | 1 |
| Autosomal Recessive Nonsyndromic Hearing Loss (DFNB9/OTOF) | 1 |
| Pendred Syndrome (SLC26A4-Related) | 1 |
| Neurodevelopmental Disorder with Hearing Loss (SPATA5L1-Related) | 4 |
| Autosomal Recessive Nonsyndromic Hearing Loss (DFNB16/STRC) | 5 |
| Usher Syndrome Type 2C (ADGRV1-Related) | 1 |
| Usher Syndrome Type 3A (CLRN1-Related) | 1 |
| Specialized Testing * | |
| Achromatopsia Type 2 (CNGA3-Related) | 1 |
| Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) | 1 |
| Bartter Syndrome Type 2 (KCNJ1-Related) | 1 |
| Gaucher Disease | 4 |
| Hereditary Sensory and Autonomic Neuropathy Type IX (TECPR2-Related) | 2 |
| Propionic Acidemia (PCCA-Related) | 1 |
| Total | 220 |
*These tests are not yet included in the standard testing panel. They were requested by families currently suffering from the aforementioned diseases to assist with shidduchim and prevent the birth of children with these diseases.
Further funding will allow the standard testing panel to include more of these debilitating diseases.
Statistically Speaking:
177 incompatible matches for debilitating diseases = 354 individuals translates into 177 men and 177 women who will Be”H not face the heartache of children born with recessive, debilitating genetic diseases.
43 incompatibles for Hearing Loss = 86 individuals
This translates into 43 men and 43 women being informed that they face the possibility of
children born with hearing loss.
