DOR YESHORIM, BY THE NUMBERS
2025 Annual Report
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- 44,567 individuals were screened for pre-marital genetic testing.
- 54,765 potential couples (109,530 individuals) called the hotline to request a compatibility check.
- 756 compatibility requests resulted in ‘incompatible’, and genetic counseling was offered to those individuals and their families (see chart below).
- 2,369 specialized tests were administered for families with rare genetic diseases.
- 472 families affected by unidentified genetic diseases have reached out to us for assistance.
The 756 incompatible results saved families from the following genetic diseases:
| Standard Panel | |
| ACM – Achromatopsia (CNGA3) | 2 |
| Aicardi-Goutieres Syndrome (AGS) | 3 |
| Congenital Megakaryocytic Thrombocytopenia (CAMT) | 9 |
| Bardet-Biedl Syndrome Type 2 (BB) | 1 |
| Bloom Syndrome (BL) | 3 |
| Canavan Disease (CN) | 19 |
| Cerebellar Ataxia And Developmental Delay | 6 |
| CNGB3-Related Achromatopsia | 1 |
| Congenital Diarrheal Neonatal | 3 |
| Congenital Heart Diseases (GDF1) | 25 |
| CPT2 Deficiency – lethal type | 1 |
| Cystic Fibrosis (CF) | 96 |
| DLD Deficiency (E3) | 21 |
| Familial Dysautonomia | 60 |
| Fanconi Anemia Type C | 6 |
| Glycogen Storage Disease Type 1A | 7 |
| Glycogen Storage Disease Type III | 1 |
| Familial Hyperinsulinemia | 19 |
| Hypomyelinating Leukodystrophy 12 | 2 |
| Inclusion Body Myopathy (IBM) | 2 |
| Joubert Syndrome | 1 |
| Leukodystrophy, Hypomyelinating 13 | 1 |
| Maple Syrup Urine Disease Type 1B (MU) | 1 |
| Mucolipidosis IV | 4 |
| Multiple Sulfatase Deficiency | 2 |
| Nemaline Myopathy Type 2 | 14 |
| Niemann Pick Disease Type A | 5 |
| Polycystic Kidney Disease | 7 |
| Rothmund-Thomson Syndrome | 5 |
| SLC1A4 Deficiency | 2 |
| Smith Lemli Opitz Syndrome | 29 |
| Spinal Muscular Atrophy | 14 |
| Tay Sachs Disease | 72 |
| Ullrich Congenital Muscular Dystrophy 1 | 1 |
| Vici Syndrome | 3 |
| Walker Warburg Syndrome | 12 |
| Warsaw Breakage Syndrome | 20 |
| Wilson’s Disease | 22 |
| Wollfram Syndrome 1 | 16 |
| 3MC Syndrome | 1 |
| Hearing Loss Panel | |
| Autosomal Recessive Deafness 77 | 1 |
| Autosomal Recessive Deafness 1B – Connexin 26 | 126 |
| Hearing Loss MPZL2 | 1 |
| Hearing Loss MYO15A | 4 |
| Hearing Loss OTOFERLIN | 2 |
| Hearing Loss OTOGL | 1 |
| Hearing Loss PEX26 | 1 |
| Hearing Loss SPATA5L1 | 6 |
| Hearing loss STRC | 16 |
| Hearing Loss TMPRSS3 | 3 |
| Pendred Syndrome | 2 |
| Usher Syndrome Type 1F | 3 |
| Usher Syndrome Type 2A | 1 |
| Usher Syndrome Type 3A | 4 |
| Specialiazed Testing* | |
| Abetalipoprotienemia (Bassen-Kornzweig Syndrome) | 1 |
| 3-Methylglutaconic Aciduria Type VIII | 1 |
| Albinism (OCA2) | 4 |
| Arthrogryposis, Mental Retardation, and Seizures | 1 |
| Bartter Syndrome Type 2 | 1 |
| Cerebrotendinous Xanthomatosis | 2 |
| Dyskeratosis Congenita | 2 |
| Familial Mediterranean Fever | 1 |
| Friedrich’s Ataxia | 2 |
| Galactosemia | 8 |
| Gaucher Disease | 15 |
| Hearing Loss LRTOMT | 1 |
| Leber Congenital Amaurosis 5 | 3 |
| Leigh Syndrome 2 | 1 |
| Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 6 | 1 |
| Osteopetrosis 1 | 1 |
| Primary Ciliary Dyskinesia, 26 | 1 |
| Primary Coenzyme Q10 Deficiency, 1 | 1 |
| Primary Coenzyme Q10 Deficiency, 7 | 1 |
| Retinis Pigmentosa 28 | 1 |
| Retinitis Pigmentosa 59 | 8 |
| SGSM3-Associated Intellectual Disability Syndrome | 2 |
| Spondylocarpotarsal Synostosis Syndrome | 1 |
| Tyrosinemia Type 1 | 4 |
| VLCAD Deficiency | 1 |
| Zellweger Syndrome (Peroxisome Biogenesis A5) | 1 |
| Total | 756 |
*These tests are not yet included in the standard testing panel. They were requested by families currently suffering from the aforementioned diseases to assist with shidduchim and prevent the birth of children with these diseases.Further funding will allow the standard testing panel to include more of these debilitating diseases.
Statistically Speaking:
584 incompatible matches for debilitating diseases = 1,168 individuals
This translates into 584 men and 584 women who will not face the heartache of children born with recessive, debilitating genetic diseases.
172 incompatibles for Hearing Loss = 344 individuals
This translates into 172 men and 172 women being informed that they face the possibility of children born with hearing loss.
