DOR YESHORIM, BY THE NUMBERS
In the past three months: April – June 2025
- 11,565 individuals were screened for pre-marital genetic testing.
- 13,773 potential couples (27,546 individuals) called the hotline to request a compatibility check.
- 190 compatibility requests resulted in ‘incompatible’, and genetic counseling was offered to those individuals and their families (see chart below).
- 532 specialized tests were administered for families with rare genetic diseases.
- 109 families affected by unidentified genetic diseases have reached out to us for assistance.
The 190 incompatible results saved families from the following genetic diseases:
| Standard Panel | |
| Aicardi-Goutieres Syndrome | 1 |
| Bloom Syndrome | 1 |
| CNGB3-Related Achromatopsia | 1 |
| Canavan Disease | 6 |
| Congenital Heart Diseases (GDF1) | 8 |
| Cystic Fibrosis | 26 |
| Dihydrolipoamide Dehydrogenase Deficiency | 7 |
| Familial Dysautonomia | 21 |
| Fanconi Anemia Type C | 2 |
| Glycogen Storage Disease Type 1A | 1 |
| Hyperinsulinism | 8 |
| Inclusion Body Myopathy (HIBM) | 1 |
| Nemaline Myopathy Type 2 | 2 |
| Polycystic Kidney Disease | 2 |
| Smith Lemli Opitz Syndrome | 5 |
| SLC1A4 Deficiency | 1 |
| Spinal Muscular Atrophy | 5 |
| Tay Sachs Disease | 16 |
| Usher Syndrome Type 1F | 2 |
| Vici Syndrome | 2 |
| Wilson’s Disease | 1 |
| Walker Warburg Syndrome | 2 |
| Warsaw Breakage Syndrome | 7 |
| Hearing Loss Panel | |
| Autosomal Recessive Deafness 1B – Connexin 26 | 29 |
| Autosomal Recessive Deafness 77 | 1 |
| Hearing Loss MYO15A | 1 |
| Hearing Loss OTOGL | 1 |
| Hearing Loss SPATA5L1 | 2 |
| Hearing loss STRC | 1 |
| Usher Syndrome Type 3A | 1 |
| Specialized Testing* | |
| Albinism | 1 |
| Arthrogryposis, Mental Retardation, and Seizures | 1 |
| Congenital Megakaryocytic Thrombocytopenia (CAMT) | 3 |
| Cerebellar Ataxia And Developmental Delay | 2 |
| Friedrich’s Ataxia | 1 |
| Galactosemia | 3 |
| Gaucher Disease | 3 |
| Hearing Loss LRTOMT | 1 |
| SGSM3-Associated Intellectual Disability Syndrome | 1 |
| Leber Congenital Amaurosis 5 | 2 |
| Osteopetrosis 1 | 1 |
| Retinitis Pigmentosa 59 | 1 |
| Tyrosinemia Type 1 | 2 |
| Wollfram Syndrome 1 | 3 |
| Zellweger Syndrome (Peroxisome Biogenesis A5) | 1 |
| Total | 190 |
*These tests are not yet included in the standard testing panel. They were requested by families currently suffering from the aforementioned diseases to assist with shidduchim and prevent the birth of children with these diseases.
Further funding will allow the standard testing panel to include more of these debilitating diseases.
Statistically Speaking:
153 incompatible matches for debilitating diseases = 306 individuals translates into 153 men and 153 women who will Be”h not face the heartache of children born with recessive, debilitating genetic diseases.
37 incompatibles for Hearing Loss = 74 individuals
This translates into 37 men and 37 women being informed that they face the possibility of
children born with hearing loss.
