DOR YESHORIM, BY THE NUMBERS
In the past three months: January – March 2025
- 12,423 individuals were screened for pre-marital genetic testing.
- 13,652 potential couples (27,304 individuals) called the hotline to request a
compatibility check. - 184 compatibility requests resulted in ‘incompatible’, and genetic counseling was
offered to those individuals and their families (see chart below). - 617 specialized tests were administered for families with rare genetic diseases.
- 112 new families suffering from yet-to-be-identified genetic diseases reached out to Dor
Yeshorim for assistance. Dor Yeshorim is working to meet their needs.
The 184 incompatible results saved families from the following genetic diseases:
| Standard Panel | |
| Achromatopsia | 1 |
| Canavan Disease | 4 |
| Congenital Cardiovascular Malformations | 4 |
| Cystic Fibrosis | 24 |
| Dihydrolipoamide Dehydrogenase Deficiency | 8 |
| Familial Dysautonomia | 13 |
| Fanconi Anemia Type C | 2 |
| Glycogen Storage Disease | 2 |
| Hyperinsulinism | 6 |
| Hypomyelination Leukodystrophy 12 | 1 |
| Joubert Syndrome | 1 |
| Mucolipidosis Type 4 | 1 |
| Nemaline Myopathy | 2 |
| Niemann Pick | 1 |
| Polycystic Kidney Disease | 2 |
| Smith Lemli Opitz Syndrome | 9 |
| Spinal Muscular Atrophy | 2 |
| Tay Sachs Disease | 20 |
| Ullrich Congenital Muscular Dystrophy 1 | 1 |
| Walker Warburg Syndrome | 1 |
| Warsaw Breakage Syndrome | 6 |
| Hearing Loss Panel | |
| Hearing Loss Connexin | 26 |
| Hearing Loss MYO15A | 1 |
| OTOFERLIN | 1 |
| Pendred Syndrome | 1 |
| PEX26 | 1 |
| SPATA5L1 | 1 |
| STEREOCILLIN | 4 |
| TMPRSS3 | 2 |
| Specialized Testing* | |
| Abetalipoprotienemia (Bassen-Kornzweig Syndrome) | 1 |
| Albinism | 1 |
| Congenital Megakaryocytic Thrombocytopenia (CAMT) | 1 |
| Cerebrotendinous Xanthomatosis | 1 |
| Primary Ciliary Dyskinesia, 26 | 1 |
| Primary Coenzyme Q10 Deficiency, 7 | 1 |
| Primary Coenzyme Q10 Deficiency, 1 | 1 |
| Dyskeratosis Congenita | 1 |
| Galactosemia | 3 |
| Gaucher Disease | 4 |
| Leber Congenital Amaurosis 5 | 1 |
| Leigh Syndrome 2 | 1 |
| Retinis Pigmentosa 28 | 1 |
| Retinitis Pigmentosa 59 | 1 |
| Rothmund-Thomson Syndrome | 2 |
| Spondylocarpotarsal Synostosis Syndrome | 1 |
| Tyrosinemia Type 1 | 2 |
| Wilson’s Disease | 7 |
| Wollfram Syndrome 1 | 4 |
| 3-Methylglutaconic Aciduria Type VIII | 1 |
| Total | 184 |
*These tests are not yet included in the standard testing panel. They were requested by families currently suffering from the aforementioned diseases to assist with shidduchim and prevent the birth of children with these diseases.
Further funding will allow the standard testing panel to include more of these debilitating diseases.
Statistically Speaking:
130 incompatible matches for debilitating diseases = 260 individuals translates into 130 men and 130 women who will Be”h not face the heartache of children born with recessive, debilitating genetic diseases.
29 incompatibles for Hearing Loss = 58 individuals
This translates into 29 men and 29 women being informed that they face the possibility of
children born with hearing loss.
